M.Sc. in Synthetic Organic Chemistry, 1997Thesis Advisor: Prof. Mark LautensThesis: Palladium Catalyzed Hydrostannations of Allenes and 1,6 Diynes: A Facile Route to Useful Synthetic IntermediatesNSERC Graduate Scholar, 1995-1997
Dennis Ostrovsky
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276 Prospect St., New Haven, CT 06511 |
e-mail:den@master.chem.yale.edu |
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phone: (203) 507-4681 |
work: (203) 432-6288 |
Education & Awards
Yale University
, New Haven, CTPh.D. in Organic Chemistry, anticipated March 2003Thesis Advisor: Prof. William L. JorgensenDissertation: Application of Monte Carlo Methods to the Study of Solvent Effects in Reactions and Estimation of Protein-Ligand Binding Affinities
University of Toronto, Toronto, Ontario, Canada
M.Sc. in Synthetic Organic Chemistry, 1997
Thesis Advisor: Prof. Mark Lautens
Thesis: Palladium Catalyzed Hydrostannations of Allenes and 1,6 Diynes: A Facile Route to
Useful Synthetic Intermediates
NSERC Graduate Scholar, 1995-1997
York University, Toronto, Ontario, Canada
B.Sc. in Chemistry, magna cum laude, 1995
Canada Scholar, 1991-1995.
NSERC Undergraduate Research Scholar, 1992-1995.
Experience
Yale University
, New Haven, CT· Applied Monte Carlo linear interaction energy methods to compute binding affinities for novel inhibitors of factor Xa. Analyzed energetic and structural results to elucidate the nature of binding interactions as an aid to future design of improved inhibitors.
· Developed force field parameters for substituted nitriles and acetylenes based on experimental results and ab initio calculations. Acetylene parameters subsequently became highly relevant in simulations of Sustiva-based HIV/RT inhibitors.
· Designed and wrote a user-friendly graphical front end for QikProp, a commercially available ADME property predictor.
· Applied QM/MM methods to study decarboxylation reactions and the effect of solvent on their rates.
University of Toronto, Toronto, Ontario, Canada
Graduate Student, 1995-1997
· Investigated the chemical and regioselectivity of Pd(OH)2/C catalyzed hydrometallations on functionalized allenes
· Discovered novel Pd catalyzed tandem hydrostannation/cyclization of diynes resulting in functionalized 1,2-exomethylene cyclopentane derivatives.
York University, Toronto, Ontario, Canada
Summer Research Assistant, 1992-1995
· Conducted cyclic voltammetry experiments on Langmuir-Blodgett monolayers of ruthenium complexes
· Explored the reactivity of alkyl peroxides present in combustion processes via semi-empirical and ab initio methods
Technical Skills
Platforms: SGI UNIX, PC Linux, Windows 9x/NT/2000/XP, Macintosh.
Development: FORTRAN, C, CSH, perl, HTML, Visual Basic.
Modeling Software: AMBER 7, BOSS, Gaussian 98, DOCK 5, MCPRO, Spartan, Midas.
Publications
Ostrovsky, D.; Jorgensen, W.L. "Binding Affinity Estimates for Selective Factor Xa Inhibitors from Monte Carlo Simulations", In Preparation.
Ostrovsky, D.; Jorgensen, W.L. "QM/MM Investigation of the Solvent Effect on the decarboxylation of both Substituted and Parent 3-carboxybenzisoxazole ", In Preparation.
Price, P. L. M.; Ostrovsky, D.; Jorgensen, W.L. "Gas-Phase and Liquid State Properties of Esters, Nitriles, and Nitro Compounds with the OPLS-AA Force Field" J. Comp. Chem. 2001, 22, 1340.
Lautens, M.; Smith, N.D.; Ostrovsky, D. "Palladium Catalyzed Hydrostannation-Cyclization of 1,6-Diynes. Generation of 1,2-Dialkylidenecyclopentanes with a Tributylstannane Moiety." J. Org. Chem. 1997, 62, 8970.
Lautens, M.; Ostrovsky, D.; Tao, B. "Regioselective Hydrostannation of Allenes Catalyzed by Pd(OH)2/C" Tetrahedron Letters 1997, 38, 6343.
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Dr. William L. Jorgensen Department of Chemistry Yale University P.O. Box 208107 New Haven, CT 06520-8107 Phone: (203) 432-6278 Email: bill@adrik.chem.yale.edu |
Dr. David Austin Department of Chemistry Yale University P.O. Box 208107 New Haven, CT 06520-8107 Phone: (203) 432-3962 Email: david.austin@yale.edu |
Dr. John Wood Department of Chemistry Yale University P.O. Box 208107 New Haven, CT 06520-8107 Phone: (203) 432-5991 Email: john.wood@yale.edu |